Intensive Wrinkle Serum

#1 Polypeptide Wrinkle and Firming Serum
  • Description
  • What’s In It
  • Skin Science

Key Benefits: Volumizing, Firming, Discoloration, Rejuvenation

The Intensive Wrinkle Serum is the ultimate defense against five common signs of aging: forehead lines, frown lines, crow lines, bunny lines, and smile lines. Made with multiple signal peptides that trigger collagen production, boost cellular repair, and smooth and blur facial lines. This formula improves skin contour and texture, while boosting skin elasticity, and brightening skin tone.


Skin Types: All Skin Types 


Skin Concern: Fine lines and wrinkles, Sagging skin, Neck firming


Size: 1 oz (30 gr)


How to use:

AM: After cleansing and toning, apply 3-4 drops to the entire face and neck twice daily for maximum results. Complete with appropriate DBH moisturizer. Follow with EGF UV Shield SPF product in the daytime.

PM: After cleansing and toning, apply 3-4 drops to the entire face and neck twice daily for maximum results. Complete with appropriate DBH moisturizer. Follow with EGF UV Shield SPF product in the daytime.

Key Ingredients:


Glycosaminoglycans: Regulation of cell growth, proliferation, promotion of cell adhesion, anticoagulation, and wound repair


Palmitoyl hexapeptide-12: Creates a response in the dermis of the skin that stimulates collagen and elastin fibroblasts, developing fibronectin and glycosaminoglycans


Acetyl hexapeptide-37: Acetyl hexapeptide-37 is a synthetic peptide composed of the amino acids alanine, proline, serine and glycine. This peptide works with the water channels (known as aquaporins) in skin’s surface layers, helping to provide adequate, balanced hydration between skin’s layers, a process which alleviates signs of dry, dehydrated skin


Acetyl tetrapeptide-2: Counteracts sagging and aging effects by increasing collagen production and functional elastin, which allows skin to return to its initial state after stretching or contracting 


Caprooyl Tetrapeptide-3: A synthetic or plant-derived signal peptide that’s said to help to boost the natural production of supportive substances skin needs to look younger and feel firmer


Ergothioneine: Supports cell health and repair of sun damage


Hyaluronic acid: Naturally found in the dermis of the skin, acts as a moisture binder to retain moisture in the skin 1000 times its weight in water.

Glycosaminoglycans: Glycosaminoglycans help support and strengthen the collagen in your skin and provide a soothing sensation to your skin.

Customer Reviews

Based on 21 reviews

I've been using the serum for about a week, 2x daily on my forehead. Unfortunately, I have not noticed results like other reviewers have mentioned. Hopefully, I'll see results in another week.

Liquid magic!

I'm on my second bottle now and must say I can't live with out this stuff!! I have noticed a big difference in the appearance of my skin

Beautiful skin

My face was tending to sag and my smile lines are getting deep. This helped improve the firmness of my skin. My face is has lifted and has a bounce to it. My smile lines are fading.

Skin looks amazing in the am

I love how my skin looks in the morning, and I can see a difference in my not-so-fine lines.


Love this serum so much! Makes my skin feel soft and smooth and also smooths creases here and there on my face.

Best ever

Best serum I've ever used. Been using it for 3 weeks and have noticed a huge difference in fine lines.


This serum seems to really diminish wrinkled skin and improve a better appearance of smooth skin.

Great gift

I bought it for my mom and she is in love with this product.

Get your band for your buck

Love that it comes with two bottles!

Firming and hydrating

Love this product! Definitely firming and hydrating! Loved my skin so much with this product.





Professional-Grade Self-Care

boost collagen production and smooth fine lines and wrinkles

repair skin cells and protect against environmental damage

brighten skin tone and complexion

Skin Perfecting Polypeptides

Environmental and biological factors like ultraviolet light, pollution, and collagen loss accelerate damage to our skin resulting in fine lines and wrinkles. Intensive Wrinkle Serum is made with revolutionary peptides that repair, replenish, and nourish skin while reversing the cause of wrinkles at the source.

How to Use

After cleansing and toning, apply 3-4 drops of serum twice daily for maximum results. Complete with an appropriate Dermaesthetics moisturizer.

Wrinkles may be a part of life, but they don't have to be. Introducing the Dermaesthetics Intensive Wrinkle Serum, the new anti-aging serum that fights wrinkles and aging skin with clinically proven peptides!

Our proprietary formula features Glycoamino glycans, palmitoyl hexapeptide-12, acetyl hexapeptide-37, Acetyl tetrapeptide-2, and Caprooyl Tetrapeptide-3.

These ingredients work together to fight wrinkles and aging skin by increasing cellular renewal and fortification for a younger-looking complexion in as little as 7 days.

Aging in our skin occurs as our skin slows its 28 day renewal process and damaged skin occurs more frequently due to weakened cells. Over time, environmental and biological factors like ultraviolet light, aging, and gravity take a toll on our skin.

In turn, wrinkles begin to form, deepen, and darken. That’s why our Intensive Wrinkle Serum is made using skin-enhancing peptides designed to smooth fine lines, improve skin contour and texture, boost skin elasticity, brighten tone and complexion, and reduce wrinkles while bolstering skin health.