Copper Peptide Serum + Anti-Pollution Foxfire Serum

$149.80 $214

Copper Peptide Serum

REVERSE THE SIGNS OF BIOLOGICAL SKIN AGING WITH THE BENEFITS OF COPPER PEPTIDE.

Encourage healthy cell turnover and nourishment to provide a glowing and radiant complex, while achieving firmer and tighter skin.

Anti-Pollution Foxfire Serum

CREATE A PROTECTIVE SKIN BARRIER TO FIGHT OFF FREE RADICALS AND ENVIRONMENTAL POLLUTANTS.

It is formulated to strengthen the skin barrier by preventing the breakdown of collagen and protect the skin from environmental pollutants such as dirt, debris, smog, and free radicals.

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MADE IN
USA

NATURAL
INGREDIENTS

CRUELTY
FREE

ADVANCED
FORMULATION

THE POWER OF COPPER PEPTIDES

Copper peptides (GHK-CU) are naturally occurring proteins in the body that are released to aid in tissue repair with cell-protective and cell-repairing properties.

A number of clinical studies established that GHK-CU stimulates the synthesis of collagen, production of selected glycosaminoglycans (like hyaluronic acid), and modulates matrix metalloproteinases (MMPs).2

This regulation helps prevent both buildup of damaged proteins and excessive proteolytic (protein breakdown). All of this leads to skin regeneration and improved appearance of the skin.

2 Siméon A., Wegrowski Y., Bontemps Y., Maquart F.X. Expression of glycosaminoglycans and small proteoglycans in wounds: Modulation by the tripeptide-copper complexglycyl-L-histidyl-L-lysine-Cu( 2+ ) J. Investig. Dermatol. 2000;115:962–968. doi: 10.1046/j.1523-1747.2000.00166.x.

THE POWER OF OLIGOPEPTIDES

Oligopeptides are smaller protein molecules that can be absorbed deeper into the skin cellular level and assist in producing more collagen and stronger skin cells, leading to the improved appearance of fine lines and wrinkles, while strengthening the skin barrier against environmental pollutants and UV rays sun damage.

SH-Oligopeptide-1 are epidermal growth factor (EGF) oligopeptides that speed up the cell turnover cycle renewal rate and provides advanced protection against cell damage (which leads to aging).

A number of clinical studies established significant increases in skin elasticity, brightness, and a decrease in skin sagging using this skincare ingredient. Application of EGF peptides increased hydration and moisture retention.2

2 Fisher, N. andCarati, D. (2020) Application of SyntheticPeptides to Improve Parameters of SkinPhysiology: An Open Observational 30-DayStudy. Journal of Cosmetics, Dermatological Sciences and Applications, 10, 163-175.

COPPER PEPTIDE SERUM

COPPER PEPTIDE (GHK-CU) HAS BEEN FOUND TO TIGHTEN LOOSE SKIN AND IMPROVE ELASTICITY, SKIN DENSITY, AND FIRMNESS, REDUCE FINE LINES AND WRINKLES, REDUCE PHOTODAMAGE AND HYPERPIGMENTATION, AND INCREASE KERATINOCYTE PROLIFERATION (NEW SKIN CELLS)."1

1 Siméon A., Wegrowski Y., Bontemps Y., Maquart F.X. Expression of glycosaminoglycans and small proteoglycans in wounds: Modulation by the tripeptide-copper complexglycyl-L-histidyl-L-lysine-Cu( 2+ ) J. Investig. Dermatol. 2000;115:962–968. doi: 10.1046/j.1523-1747.2000.00166.x.

ANTI-POLLUTION FOXFIRE SERUM

ADENOSINE IS A NATURAL INGREDIENT PRODUCED WITH THE AID OF OLIGOPEPTIDES, COENZYMES, AND VITAMINS. STUDIES SUGGEST THAT ADENOSINE CAN ASSIST IN SKIN HEALING AND ANTI-AGING BENEFITS TO PRODUCE HEALTHY GLOWING SKIN AND REDUCED APPEARANCE OF AGING.1

1 Bonyanian Z, Walker M, Du Toit E, Rose'Meyer RB. Multiple adenosine receptor subtypes stimulate wound healing in human EA.hy926 endothelial cells. Purinergic Signal. 2019 Sep;15(3):357-366. doi: 10.1007/s11302-019-09668-z. Epub 2019 Jun 28. PMID: 31254200; PMCID: PMC6737157.

REVERSE THE SIGNS OF BIOLOGICAL AGING

The Copper Peptide Serum is formulated with a potent dosage of GHK-CU Copper Peptide, plant stem cells, multi-vitamins, antioxidants, moisturizers, and skin firming amino acids aiming to collectively tighten, thicken, repair, recover, and reverse the signs of biological skin aging.

Improves skin firmness, elasticity, and clarity

Tightens loose skin and reverses thinning of aged skin

Smooths rough skin for more even skin texture

Repairs protective skin barrier proteins

Reduces fine lines, depth of wrinkles, and improves structure of aged skin

Reduces inflammation and free radical damage

Reduces photodamage, mottled hyperpigmentation, skin spots and lesions

Protects skin cells from UV radiation and stimulates wound healing

FIGHT OFF FREE RADICALS AND PROTECT AGAINST POLLUTANTS

The Anti-Pollution Foxfire Serum stimulates adenosine (ATP) production which can soothe the skin, support wound healing, and the natural reparative functioning of the skin. The serum applies smoothly and repairs the skin deep within the epidermis with the use of peptide growth factors and energy formation in the skin cells.

Prevention of fine lines and wrinkles

Wound-healing and skin-healing benefits

Healthy glowing skin

Forms protective skin barrier

Prevent breakdown of collagen in skin cells

Reduce appearance of skin blemishes

COMPLETE YOUR TREATMENT

CLEANSER

GREEN APPLE PREMIUM CLEANSING OIL

Easy to use emulsifying oil (converts from oil to water leaving no oily residue)

Prepares skin with proper clinical cleansing

Effective at removing makeup, dirt, debris, and environmental pollutants

TONER

SALIX TONE

Excellent for oily and acne-prone skin

Reduces pore size and balances sebum production

Provides clean, fresh, and brighter complexion without drying the skin

MOISTURIZER

ADVANCED COLLAGEN FORMULA

Provides instant gratification with supple and buoyant skin

Quickly penetrates and moisturizes

Excellent for people who wear make-up and/or have mature skin

SUN PROTECTION

UV SHIELD: EGF FGF DNA 

Lightweight and blendable under makeup

Waterproof and reef-safe
Non-comedogenic (won’t block pores)

Biologically-active polypeptides combat fine lines and wrinkle

CLEANSER

GREEN APPLE PREMIUM CLEANSING OIL

Easy to use emulsifying oil (converts from oil to water leaving no oily residue)

Prepares skin with proper clinical cleansing

Effective at removing makeup, dirt, debris, and environmental pollutants

TONER

SALIX TONE

Excellent for oily and acne-prone skin

Reduces pore size and balances sebum production

Provides clean, fresh, and brighter complexion without drying the skin

MOISTURIZER

ADVANCED COLLAGEN FORMULA

Provides instant gratification with supple and buoyant skin

Quickly penetrates and moisturizes

Excellent for people who wear make-up and/or have mature skin

SUN PROTECTION

UV SHIELD: EGF FGF DNA 

Lightweight and blendable under makeup

Waterproof and reef-safe
Non-comedogenic (won’t block pores)

Biologically-active polypeptides combat fine lines and wrinkle

Our Customers

Read actual testimonials from happy, healthy clients of Crunchy. We are grateful for our customers & the transformations they have because of our natural food products. See for yourself the difference Crunchy has made!

About Nature’s Path

The seed for Nature’s Path was planted way back in the 1930s when Arran Stephens was growing up on his family’s second-generation organic berry farm. Arran’s father taught him how to care for and nurture the soil, telling him to “always leave the earth better than you found it”. These words have been woven into the very fabric of Nature’s Path.

Morning routine

STEP 1. APPLY THE COPPER PEPTIDE SERUM

apply enough to lightly cover your entire face, avoiding the eye area, gently tapping into the skin

STEP 2. APPLY THE ANTI-POLLUTION FOXFIRE SERUM

apply enough to lightly cover your entire face, avoiding the eye area, gently tapping into the skin

STEP 3. FINISH WITH SUN PROTECTION

protect your skin from harmful UV rays, even if you're staying indoors: UV Shield: EGF FGF DNA Sunblock

Night routine

STEP 1. APPLY THE COPPER PEPTIDE SERUM

apply enough to lightly cover your entire face, avoiding the eye area, gently tapping into the skin

STEP 2. APPLY THE ANTI-POLLUTION FOXFIRE SERUM

apply enough to lightly cover your entire face, avoiding the eye area, gently tapping into the skin

STEP 3. FINISH WITH A MOISTURIZER

nourish and keep your skin hydrated while you sleep: Multi Cream

How does it work?

Explained by our cosmetic chemist,
Dr. Ann Lee

"The Copper Peptide Serum immediately begins by nourishing and protecting the mitochondrial process (energy production) and then moves swiftly to accelerate the growth of epidermal cells, which results in healthier skin and reduced wrinkles. Then a biomimetic peptide is tagged and it starts to boost collagen production and activate skin repair, while protecting the skin from environmental stressors."

"The Anti-Pollution Foxfire Serum focuses on the body's natural creation of the organic compound adenosine, which is formed by the hydrolysis of yeast nucleic acids. Adenosine triphosphate (ATP) is a nucleotide consisting of an ester of triphosphoric acid with ribose (monosaccharide) and a glycoside bond with the purine base adenine. Research has shown that ATP appears to have strong potential as a skin-restoring ingredient and as a soothing agent."

KEY INGREDIENTS

ANTI-POLLUTION FOXFIRE SERUM: EGF Peptides (SH-Oligopeptide-1), Niacinimide (Vitamin B3) , Biotin (Vitamin B7), Ubiquinone (Coenzyme Q), Aesculus Hippocastanum (Horse Chestnut), Panthenol (Pro-Vitamin B5)

COPPER PEPTIDE SERUM: GHK-CU (Copper Peptide), Ubiquinone (CoQ10), Thioctic (R-lipoic) Acid, Zea Mays, Phenyl-N-Butyl Nitrone (Spin Trap), Acetyl Carnitine (L), Adenine, Hydrolyzed Rice (Peptide) Protein, Malus Domestica (Apple) Fruit Cell Culture Extract, Rubus Villosus (Blackberry) Fruit Extract, Phyllanthus Emblica (Amla) Fruit Extract

RESEARCH: COPPER PEPTIDE SERUM

Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. PMID: 29986520; PMCID: PMC6073405.

Pickart L. The human tri-peptide GHK and tissue remodeling. J. Biomater. Sci. Polym. Ed. 2008;19:969–988. doi: 10.1163/156856208784909435.

Siméon A., Wegrowski Y., Bontemps Y., Maquart F.X. Expression of glycosaminoglycans and small proteoglycans in wounds: Modulation by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu(2+) J. Investig. Dermatol. 2000;115:962–968. doi: 10.1046/j.1523-1747.2000.00166.x.Wegrowski Y., Maquart F.X., Borel J.P. Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+ Life Sci. 1992;51:1049–1056. doi: 10.1016/0024-3205(92)90504-I.

Siméon A., Monier F., Emonard H., Gillery P., Birembaut P., Hornebeck W., Maquart F.X. Expression and activation of matrix metalloproteinases in wounds: Modulation by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+ J. Investig. Dermatol. 1999;112:957–964. doi: 10.1046/j.1523-1747.1999.00606.x. Siméon A., Emonard H., Hornebeck W., Maquart F.X. The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 2000;22:57–65. doi: 10.1016/S0024-3205(00)00803-1.

Pickart L. Ph.D. Thesis. University of California; San Francisco, CA, USA: 1973. A tripeptide in Human Serum That Promotes the Growth of Hepatoma Cells and the Survival of Normal Hepatocytes.

Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108. doi: 10.1155/2015/648108. Epub 2015 Jul 7. PMID: 26236730; PMCID: PMC4508379.

Leyden J., Stephens T., Finkey M., Appa Y., Barkovic S. Skin Care Benefits of Copper Peptide Containing Facial Cream; Proceedings of the American Academy of Dermatology 60th Annual Meeting; New Orleans, LA, USA. 22–27 February 2002; p. 68.

Finkley M., Appa Y., Bhandarkar S. Copper Peptide and Skin. In: Elsner P., Maibach H., editors. Cosmeceuticals and Active Cosmetics: Drugs vs. Cosmetics. Marcel Dekker; New York, NY, USA: 2005. pp. 549–563.

Badenhorst T., Svirskis D., Merrilees M., Bolke L., Wu Z. Effects of GHK-Cu on MMP and TIMP Expression, Collagen and Elastin Production, and Facial Wrinkle Parameters. J. Aging Sci. 2016;4:166. doi: 10.4172/2329-8847.1000166

RESEARCH: ANTI-POLLUTION FOXFIRE SERUM

Holzer AM, Granstein RD. Role of extracellular adenosine triphosphate in human skin. J Cutan Med Surg. 2004 Mar-Apr;8(2):90-6. doi: 10.1007/s10227-004-0125-5. Epub 2004 May 3. PMID: 15129319.

Reddy B, Jow T, Hantash BM. Bioactive oligopeptides in dermatology: Part I. Exp Dermatol. 2012 Aug;21(8):563-8. doi: 10.1111/j.1600-0625.2012.01528.x. Epub 2012 Jun 4. PMID: 22672743.

Kim, H.J., Jung, M.S., Shin, J.M. et al. Verification of air brush effectiveness using cosmeceutical ingredients. Biomedical Dermatology. 2, 24 (2018).

Fisher, N. andCarati, D. (2020) Application of SyntheticPeptides to Improve Parameters of SkinPhysiology: An Open Observational 30-DayStudy. Journal of Cosmetics, Dermatological Sciences and Applications, 10, 163-175

Yeo, S.; Jung, S.; Cho, H.K.;Kim, Y.H.; Kim, G.H.; Kim, D.;Ko, B.H.; Lee, J. Design andCharacterization of Elastic ArtificialSkin Containing Adenosine-LoadedSolid Lipid Nanoparticles for TreatingWrinkles. Pharmaceutics 2021, 13, 33.
M.L. Abella, Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique, International Journal of Cosmetic Science, 10.1111/j.1467-2494.2006.00349.x, 28, 6, (447-451), (2006).

Nakav S, Chaimovitz C, Sufaro Y, Lewis EC, Shaked G, Czeiger D, et al. (2008) Anti-Inflammatory Preconditioning by Agonists of Adenosine A1 Receptor. PLoS ONE 3(5): e2107. https://doi.org/10.1371/journal.pone.0002107

Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V.Belsito, M.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D., Ronald C. Shank, Ph.D.;Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D., Safety Assessment of Adenosine Ingredients, Cosmetic Ingredient Review 2019.

Bonyanian, Z., Walker, M., Du Toit, E. et al. Multiple adenosine receptor subtypes stimulate wound healing in human EA.hy926 endothelial cells. Purinergic Signalling 15, 357–366 (2019).

Perez-Aso M, Fernandez P, Mediero A, Chan ES, Cronstein BN. Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3. FASEB J. 2014 Feb;28(2):802-12. doi: 10.1096/fj.13-241646. Epub 2013 Nov 7. PMID: 24200882; PMCID: PMC3898645.

Aldag C, Nogueira Teixeira D, Leventhal PS. Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature. Clin Cosmet Investig Dermatol. 2016 Nov 9;9:411-419. doi: 10.2147/CCID.S116158. PMID: 27877059; PMCID: PMC5108505.